Process of manufacturing new pharmaceutical preparations.



UNITED STATES PAETENT OFFICE.

ElVIIL SCHEITLIN, OF BASEL, AND ERICH KUNZ, OF GENEVA, SWITZERLAND,ASSIGN- ORS TO LEON G-IVAUDAN, 0F GENEVA, SWITZERLAND, AND EIVIILSCHEITLIN, 0F

BASEL, SWITZERLAND.

PROCESS OF MANUFACTURING NEW PHARMACEUTICAL PREPARATIONS.

No Drawing.

Specification of Letters Patent.

Application filed March 29, 1912.

Patented July 22, 1913.

Serial No. 687,170.

1 b all whom it may concern:

Be it known that. we, Elwin SGHEITL'IN', a citizen of the SwissConfederation, and residing at Basel, Switzerlaml, and Enron litmz, acitizen of the Swiss Confederation, and residing at Geneva, Switzerland,have invented a certain new and useful Improved Process of Manulacturing New Pharmacelu tical Preparations, of which the following is a.specification.

Our invention relates to a process oi? manutz'uituring new pharn'laceuti'al preparations.

The actions of 1-phenyl-2.3-dimethyl-opyrazolonc, oit'l-phenyl-itl-dimethyll-diniethylamino-S-pyrazolone and ofacetyl-pphenetidin on the living organism are wellknown and the resultsof the investigations relating thereto are described in scientificjournals. Now we have found that when all the said three bodies areemployed together either as a simple mixture or a crystallized productof two or more, or mixtures of crystallized products the beneficialproperties of each individually are combined, while the undesirableactions of the individual bodies disappear owing to the small dose ofthe individual components. This exceedingly valuable result could not beit'oreseen; on the contrary, the supposition was th at thepllarmacodynamically strongest or most rapidly operative component forexample, the .l phenyl 2.3 diniethyl pyrazolone, would not allow theother bodies to act at all. lonsiderable diszulvantages are howeverconnected with the eniployment of the three bodies in their simplestform, 2'. 0. mixed together. The mixture is not very stable. Withoutbeing exactly hygroscopic it has a tendency to deliquesce in air whichnot dry or when great changes in temperature occur. Further, it ispossible for the mixture to separate into its component parts. We havefound also that these defects can be largely obviated by melting thethree bodies together, whereupon they congeal in a crystalline form, orwhen they are crystallized together. It preferred, however, doublecompounds may be made oi? each two of the components and the doublecompounds thus obtained mixed or crystallized.

Example 1: 2 molecules of l-phenylfiJ-ldimethyl-5-pyrazolone and 1molecule of acetyl.p-pheiietidin are dissolved in hot toluol; when cold,uniform crystals of the double compound having a melting point at 80 C.are obtained.

Exantq ile .2: 2 molecules of l-phcnyl-2.3-dimethyl-4;-dimethylamino-o-pyrazoloneand 1. molecule ofacetyl-p-phenetidin are treated as in Example 1. The melting point ofthe crystals is about 80 0.

Example 3: Equal parts by weight of the bodies obtained according toExamples 1 and 2 are mixed together or molecularly crystallizedtogether. The product melts at 80 C.

lVe claim:

1. A new article, comprising l-phenyl-Qi-ldimethyl-o-pyrazolone andg'acetyl-p-phcnetidin crystallized together.

2 As a new article of manu'tacture, a body composed ofl-phenyl-2.3dimethyl- 5 pyrazolone, 1 phenyl 2.3 dimethyl 4t:liniethylamino-5-pyrazolone and acetyl-pphcnctidin.

23. A new article, comprising crystals contaii'iing1-phcnyl-2.3-din1ethyl-opyrazolone; l-phenyl-QJ-Ldim ethyl 4;dimethylamino 5- pyrazolone and acetyl-p-phenetidin.

In testimony whereof, we allix our signatures in the presence of twowitnesses.

EMIL SGHEITLIN. ERIOH KUNZ.

Witnesses Louis H. Momma, F. VILLnin.

Copies of this patent may be obtained for five cents each, by addressingthe Commissioner of Patents,

Washington, D. C.

